Bifunctional Molecular Linchpins: A Three-Component Coupling Protocol Employing 2-Bromoallyltrimethylsilane
| Autor: | III, Amos B. Smith |
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| Zdroj: | Synlett; July 2004, Vol. 2004 Issue: 8 p1363-1366, 4p |
| Abstrakt: | A new three-component coupling protocol, exploiting 2-bromoallyltrimethylsilane as a bifunctional linchpin, has been developed. The reaction sequence entails the following steps: lithiation of the vinyl bromide, addition of an aromatic or aliphatic aldehyde, execution of a solvent controlled 1,4-Brook rearrangement induced by HMPA to generate an allyl anion, and addition of a reactive second electrophile. Yields are moderate to good. |
| Databáze: | Supplemental Index |
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