| Autor: |
Niegemann, Eckhard, Brendel, Martin |
| Zdroj: |
Mutation Research/DNA Repair; November 1994, Vol. 315 Issue: 3 p275-279, 5p |
| Abstrakt: |
Molecular characterization of a thermoconditional mutant snm1–2tsshows that the coding sequence contains three mutations, two of which are silent. The third changes amino acid glycine to arginine at position 256 thereby altering a hydrophilic domain of the protein. While sensitivity to nitrogen mustard of the mutant at 36°C is very similar to that of the non-leaky allele snm1-1, multi-copy vector-mediated overexpression of snm1–2tsleads to a significantly reduced sensitivity to nitrogen mustard. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
