| Autor: |
Wang, Ci-Li, Jin, Tian-Yun, Liu, Xue-Huan, Zhang, Jia-Rui, Shi, Xing, Wang, Meng-Fei, Huang, RunFeng, Zhang, Yun, Liu, Ke-Chun, Li, Guo-Qiang |
| Zdroj: |
Organic Letters; December 2022, Vol. 24 Issue: 49 p9007-9011, 5p |
| Abstrakt: |
Five new furanobutenolide-derived C19-norcembranoid diterpenes, sinudenoids A–E (1–5, respectively), were isolated from the soft coral Sinularia densa. Sinudenoid A (1) possesses an uncommon 5/5/11-fused tricyclic ring system. Sinudenoids B–D (2–4, respectively) share the same tetracyclic 5/5/6/6 ring system but represent two kinds of new skeletons. Sinudenoid E (5) is the second compound with the rare 8/8 bicyclic carbon core. A plausible biosynthesis pathway for compounds 1–6is proposed. Compound 5exhibits strong anti-inflammatory activity in the zebrafish model. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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