| Autor: |
de Cock, J.G.R., Klink, E.C., Lohman, P.H.M., Eeken, J.C.J. |
| Zdroj: |
Mutation Research/DNA Repair; August 1992, Vol. 274 Issue: 2 p85-92, 8p |
| Abstrakt: |
Strand-specific excision repair of UV-induced cyclobutane pyrimidine dimers was investigated in three genes: Gart, Notchand whitein the permanent Kccell line derived from wild-type Drosophila melanogasterembryonic cells. In this cell line Gartand Notchare transcriptionally active, whereas whiteis not expressed. Cells were irradiated with 10 or 15 J/m2ultraviolet (UV) light (predominantly 254 nm). In all three genes, cyclobutane pyrimidine dimers were removed from the non-transcribed strand at the same rate and to the same extent as from the transcribed strand, indicating the absence of strand-specific repair in permanent Drosophila embryonic cell lines. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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