| Autor: |
Balasubramanian, Radha, Hofert, John F., Heidrick, Margaret L. |
| Zdroj: |
Immunopharmacology; October 1985, Vol. 10 Issue: 2 p83-88, 6p |
| Abstrakt: |
One week following induction of diabetes in rats by alloxan administration, the thymus and spleen showed marked involution and a highly significant depression of in vivo incorporation of [3H]deoxycytidine into the DNA of these tissues. Adrenalectomy of diabetic rats reduced the decline of lymphatic tissue weight, but uptake of [3H]deoxycytidine into thymic and spleen DNA remained suppressed. These results indicate that in alloxan-induced diabetes, the observed depressed lymphatic tissue weight and cellular proliferation are not simply due to the elevated plasma level of corticosteroids, but are either a result of the insulin deficiency per se or due to other metabolic alterations associated with the diabetic condition. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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