| Autor: |
Kraszewska, Elżbieta, Dobrzańska, Marta, Tudek, Barbara |
| Zdroj: |
Mutation Research/DNA Repair; November 1998, Vol. 409 Issue: 2 p91-95, 5p |
| Abstrakt: |
Two of the major products in DNA resulting from exposure to alkylating agents are 7-methylguanine and 3-methyladenine. N-methylpurine-DNA-glycosylase is required for excision of these lesions. Recently, the 3-methyladenine-DNA-glycosylase gene of Arabidopsis thalianawas cloned and shown to be involved only in repair of 3-methyladenine. In BY-2 tobacco cells, we showed an enzymatic activity which excised both 3-methyladenine and 7-methylguanine from methylated DNA. |
| Databáze: |
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