| Autor: |
Asad, Nasser R, Asad, Lı́dia M.B.O, Silva, André B, Felzenszwalb, Israel, Leitão, Alvaro C |
| Zdroj: |
Mutation Research/DNA Repair; June 1998, Vol. 407 Issue: 3 p253-259, 7p |
| Abstrakt: |
Pretreatment with 2.5 mM H2O2protects bacterial cells against cumene hydroperoxide killing. This response is independent of the OxyR system, but possibly involves the participation of Ahp protein, since ahpmutants are not protected. Treatment of bacterial cells with high H2O2concentrations caused an alteration on the electrophoretic profile of the smaller subunit (22-kDa) of Ahp. This alteration does not require novel gene products and is not dependent on the OxyR protein. In this way, we propose that the modification of the 22-kDa subunit of Ahp by high H2O2concentration may be responsible for the protection against the lethal effects of cumene hydroperoxide. |
| Databáze: |
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