Suboptimal exposure to fluconazole in critically ill patients: Pharmacokinetic analysis and determinants

Autor: Bienvenu, A.L., Pradat, P., Matusik, E., Piriou, V., Rimmelé, T., Parant, F., Tod, M., Leboucher, G., Goutelle, S., Ader, Florence, Argaud, Laurent, Aubrun, Frédéric, Fellahi, Jean-Luc, Guichon, Céline, Juillard, Laurent, Leclerc, Vincent, Miossec, Charline, Paillet, Carole, Plesa, Alexandra, Richard, Jean-Christophe, Roux, Sandrine, Wallet, Florent
Zdroj: Infectious Diseases Now; 20230101, Issue: Preprints
Abstrakt: •SOFA score ≥ 7 and GGT ≥ 100 associated with fluconazole underexposure.•A median loading dose of 890 mg (640–3450) needed to avoid underexposure.•Fluconazole therapeutic drug monitoring for critically ill patients.
Databáze: Supplemental Index