| Autor: |
Klemi, Pekka J., Joensuu, Heikki, Siivonen, Lasse, Virolainen, Erkki, Syrjänen, Stina, Syrjänen, Kari |
| Zdroj: |
Otolaryngology - Head and Neck Surgery; June 1989, Vol. 100 Issue: 6 p563-567, 5p |
| Abstrakt: |
The nuclear DNA content of 19 transitional papillomas of the sinonasal region and 9 maxillary squamous cell carcinomas was studied by flow cytometry; the presence of human papillomavirus (HPV) DNA types 11 and 16 was determined by the in situ hybridization technique from paraffin-embedded tissue. Thirteen (68%) of the papillomas and none of the carcinomas contained HPV genome. Six (32%) of the papillomas and 4 (44%) of the carcinomas had an aneuploid DNA content. The relative DNA content (DNA Index) of the aneuploid maxillary carcinomas was larger than that of aneuploid papillomas (p= 0.004). Three of the papillomas underwent malignant transformation, all three of which contained HPV type 16 DNA; two were also aneuplold. Data Indicate that papillomas containing HPV type 16 DNA have a tendency (p= 0.06) to undergo malignant transformation, and that this tendency Is greater If DNA aneuploidy or HPV type 11 DNA Is also present (p= 0.02). |
| Databáze: |
Supplemental Index |
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