| Autor: |
Choonong, Rattanathorn, Ruangdachsuwan, Sasiporn, Churod, Theeraporn, Palabodeewat, Somnuek, Punyahathaikul, Surat, Juntarapornchai, Sanjira, Ketsuwan, Kunjimas, Komaikul, Jukrapun, Masrinoul, Promsin, Kitisripanya, Tharita, Juengwatanatrakul, Thaweesak, Yusakul, Gorawit, Kanchanapoom, Tripetch, Putalun, Waraporn |
| Zdroj: |
Journal of Natural Products; December 2022, Vol. 85 Issue: 12 p2779-2788, 10p |
| Abstrakt: |
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, has become a pandemic and public health crisis. SARS-CoV-2 and the seasonal common cold coronavirus (HCoV-OC43) belong to the beta genus of human coronaviruses (HCoVs). In-cell ELISA assays were performed using HCoV-OC43 and SARS-CoV-2 and evaluated the antiviral activity of herbal plants. Eurycoma longifolia(EL) and Eurycoma harmandiana(EH) roots (antipyretic properties) and their constituent quassinoids, especially chaparrinone and eurycomalactone, showed potent anti-HCoV-OC43 and SARS-CoV-2 activities, and the low IC50values of the mentioned constituents were observed in the range of 0.32–0.51 μM. Eurycomanone and 13β,21-dihydroeurycomanone may contribute to the antiviral activity of EL, whereas chaparrinone is the major and active antiviral constituent of EH root. The content of quassinoids, β-carboline, and canthin-6-one alkaloids and the cytotoxicity profile of EL and EH extracts were varied regarding extraction solvents. The boiled water and 50% EtOH extractions of both plants were less toxic than those with 95% EtOH as the extraction solvent. Our research suggests that quassinoids, which come from EL and EH roots and are anti-coronavirus compounds, are potential treatment candidates for COVID-19 and merit further in vivoinvestigations. |
| Databáze: |
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