| Autor: |
Prasanth, Kesavan, Bhargava Reddy, Mandapati, Anandhan, Ramasamy |
| Zdroj: |
Asian Journal of Organic Chemistry; November 2022, Vol. 11 Issue: 11 |
| Abstrakt: |
Visible‐light‐initiated copper(I) catalyzed selective synthesis of 5‐alkynyl trisubstituted 1,2,3‐triazoles from azides and alkynes is reported. The reaction proceeded viaphotoexcited copper(I)acetylides with azides to in‐situformation of cuprate‐triazole followed by oxidative C−C(sp) coupling with another alkynes. The UV‐Visible spectrum shows that in‐situ photoexcited copper(I)acetylides (λabs=425–485 nm) is most probably the key light absorbing species responsible for CuAAC reactions. Herein, we report asimple and selective synthesis of 5‐alkynyl trisubstituted 1,2,3‐triazoles under photochemical conditions. The in‐situgenerated Cu(I)‐phenylacetylide complex is the key light‐absorbing photocatalyst involved in this CuAAC reaction. This protocol avoids external oxidants and complex ligands, showing a broad substrate scope under mild reaction conditions. |
| Databáze: |
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