| Autor: |
Costa, Anna Luisa, Blosi, Magda, Brigliadori, Andrea, Zanoni, Ilaria, Ortelli, Simona, Simeone, Felice Carlo, Delbue, Serena, D'Alessandro, Sarah, Parapini, Silvia, Vineis, Claudia, Varesano, Alessio, Toprak, Muhammet S., Hamawandi, Bejan, Gardini, Davide |
| Zdroj: |
Environmental Science: Nano; 2022, Vol. 9 Issue: 11 p4295-4304, 10p |
| Abstrakt: |
For the first time, we exploited the antiviral and antibacterial properties of Ag NPs stabilised by quaternized hydroxyethyl cellulose (Ag-HEC) against SARS-CoV-2 and Escherichia colithrough an eco-friendly process at room temperature in three different environments: 1) water, where Ag was dispersed as a nanosol, 2) textiles, where Ag was applied as a coating, and 3) hydrogel where Ag is embedded. The antiviral performance of Ag-HEC nanosols was quantified through the selectivity index (SI), defined as the ratio between 50% cytotoxic and inhibitory concentration, in order to evaluate the ability to be active in a concentration range below the cytotoxicity value. The collected results pointed out an actual enhanced risk/benefit profile of Ag-HEC NPs with respect to chloroquine, with an SI of 22.2 and 8.4, respectively. Antibacterial and antiviral activities of Ag-HEC NPs immobilized on textiles or mucosa-like hydrogels were also assessed and their efficacy in potential application as protective clothing or nasal molecular masks was verified. This work demonstrated that a modern, safe and sustainable design allows traditional colloidal silver-based technologies to be efficiently exploited for a broad spectrum of antimicrobial solutions against bacterial and viral infections. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
