| Autor: |
Ghasemi, Reza, Lotfali, Ensieh, Rezaei, Kamran, Madinehzad, Seyed Ataollah, Tafti, Mahdi Falah, Aliabadi, Nikta, Kouhsari, Ebrahim, Fattahi, Mahsa |
| Zdroj: |
Brazilian Journal of Microbiology; December 2022, Vol. 53 Issue: 4 p1761-1779, 19p |
| Abstrakt: |
Meyerozyma guilliermondiihas been accepted as a complex composed of Meyerozyma guilliermondii, Meyerozyma carpophila, and Meyerozyma caribbica. M. guilliermondiiis a saprophyte detected on human mucosa and skin. It can lead to serious infections in patients with risk factors like chemotherapy, immunodeficiency, gastrointestinal or cardiovascular surgery, and oncology disorders. Most deaths related to M. guilliermondiiinfections occur in individuals with malignancy. In recent decades, incidence of M. guilliermondiiinfections is increased. Sensitivity of this microorganism to conventional antifungals (e.g., amphotericin B, fluconazole, micafungin and anidulafungin) was reduced. Prophylactic and empirical uses of these drugs are linked to elevated minimal inhibitory concentrations (MICs) of M. guilliermondii.Drug resistance has concerned many researchers across the world. They are attempting to discover appropriate solution to combat this challenge. This study reviews the most important mechanisms of resistance to antifungals developed by in M. guilliermondiispecies complex. |
| Databáze: |
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