| Autor: |
Babakuliyev, Alisir, Maiti, Niladri, Antony, Annie Aglin, Ansari, Mohammad Javed, Chobe, Santosh S., Dixit, Chandra Kumar |
| Zdroj: |
Advances in Science and Technology; August 2022, Vol. 117 Issue: 1 p73-78, 6p |
| Abstrakt: |
This paper reports the G-rich ssDNA for the colorimetric detection of cancer cells. The ssDNA-1 sequence has explored for the potential application of “Turn-On” colorimetric sensor for selective and sensitive detection of cancer cells. While complementary G-rich DNA strand form G-quadruplex with hemin molecule, which is more effective to catalyze the peroxidase mimicking activity towards TMB chromogenic substrate. The ssDNA-1 exhibits good selectivity for cancer cells. The colorimetric intensity of TMB was enhanced upon interaction of leukemic lymphoblasts cancer cells. The effect of pH has turned the selective sensing performances of the biosensor for detecting cancer cells with a lower detection limit of 0.54 nM, 0.18 nM, and 0.2 nM respectively. |
| Databáze: |
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