| Autor: |
Co¨lkesen, Fatih, Kepenek Kurt, Esma, Vatansev, Hu¨lya, Korkmaz, Celalettin, Co¨lkesen, Fatma, Yu¨cel, Fatih, Yıldız, Eray, Evcen, Recep, Aykan, Filiz Sadi, Kılınc, Mehmet, Aytekin, Go¨khan, Feyzioğlu, Bahadır, Doğan, Metin, Arslan, Sevket, Teke, Turgut, Keles, Sevgi, Reisli, İsmail |
| Zdroj: |
Postgraduate Medical Journal; 2022, Vol. 98 Issue: 1164 p765-771, 7p |
| Abstrakt: |
Purpose of the studyThe aim of this study was to investigate the relationship of B cell-mediated immunity with disease severity and mortality in patients with COVID-19.Study designIn this retrospective cohort and single-centre study, 208 patients with laboratory-confirmed COVID-19 were recruited. A COVID-19 severity score, ranging from 0 to 10, was used to evaluate associations between various factors. Serum immunoglobulin levels and the number of cells in B lymphocyte subsets were measured and their association with disease severity and mortality in patients with COVID-19 examined.ResultsThe median age of the patients was 50 (35–63) years and 88 (42%) were female. The number of deceased patients was 17. The median COVID-19 severity score was 8 (6–8) in deceased patients and 1 (0–2) in survivors. Deceased patients had significantly lower levels of total B lymphocytes, naive B cells, switched memory B cells, and serum IgA, IgG, IgG1and IgG2than recovered patients (all p<0.05). In addition, a significant negative correlation was found between the number of these parameters and COVID-19 severity scores. Decrease in the number of total B cells and switched memory B cells as well as lower serum IgA, IgG and IgG1levels were independent risk factors for mortality in patients with COVID-19.ConclusionIn the present study, the prognosis of patients with COVID-19 was shown to be associated with the B cell subset and serum immunoglobulin levels. |
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