| Autor: |
Ishibashi, Fumito, Fukuda, Tsutomu, Zha, Shijiao, Hashirano, Aya, Hirao, Shotaro, Iwao, Masatomo |
| Zdroj: |
Bioscience, Biotechnology, and Biochemistry; January 2021, Vol. 85 Issue: 1 p181-191, 11p |
| Abstrakt: |
Benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs) are potent anticancer compounds having unique BBPIs ring system designed on the basis of the marine natural product lamellarin D. In this study, we describe an alternative synthesis of a 2-demethoxy series of BBPIs, employing van Leusen pyrrole synthesis and an intramolecular Heck reaction as the key reactions. Cytotoxicity of the derivatives against several cancer and normal cell lines is reported.Graphical Abstract |
| Databáze: |
Supplemental Index |
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