| Autor: |
e Silva, Joanda P. R., Pereira, Laiane C. O., Abreu, Lucas S., Lins, Francisca S. V., de Souza, Thalisson A., do Espírito-Santo, Renan F., Barros, Renata P. C., Villarreal, Cristiane F., de Melo, José I. M., Scotti, Marcus T., Costa, Vicente C. de O., Martorano, Lucas H., dos Santos, Fernando M., Filho, Raimundo Braz, da Silva, Marcelo S., Tavares, Josean F. |
| Zdroj: |
Journal of Natural Products; September 2022, Vol. 85 Issue: 9 p2184-2191, 8p |
| Abstrakt: |
Herein, the isolation of secondary metabolites from the aerial parts of Justicia aequilabrisguided by HPLC-MSnand molecular networking analyses is reported. Twenty-two known compounds were dereplicated. Three new lignans (aequilabrines A–C (1–3)) and three known compounds (lariciresinol-4′-O-β-glucose (4), roseoside (5), and allantoin (6)) were obtained. The anti-inflammatory activity of compounds 1–3was evaluated in vitroby inhibiting the nitric oxide production (NO) and pro-inflammatory activity on the cytokine IL-1β. Compounds 2and 3showed significant inhibitory activity against NO production, with IC50values of 9.1 and 7.3 μM, respectively. The maximum inhibition of IL-1β production was 23.5% (1), 27.3% (2), and 32.5% (3). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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