Expedient Protocol for Solid-Phase Synthesis of Secondary and Tertiary Amines

Autor: Olsen, C. A., Witt, M., Jaroszewski, J. W., Franzyk, H.
Zdroj: Organic Letters; June 2004, Vol. 6 Issue: 12 p1935-1938, 4p
Abstrakt: An expedient solid-phase synthetic approach to secondary and tertiary amines was developed. The protocol employs conversion of resin-bound amino alcohols to the corresponding iodides, followed by iodide displacement with primary or secondary amines or with unprotected amino alcohols. This two-step procedure, affording products in good to excellent yields, is suitable for solid-phase synthesis of polyamines.
Databáze: Supplemental Index