| Autor: |
Kanagy, William K., Cleyrat, Cédric, Fazel, Mohamadreza, Lucero, Shayna R., Bruchez, Marcel P., Lidke, Keith A., Wilson, Bridget S., Lidke, Diane S. |
| Zdroj: |
Molecular Biology of the Cell; August 2022, Vol. 33 Issue: 10 |
| Abstrakt: |
Kanagy et al. combine biochemical and fluorescence microscopy methods to determine the interplay between positive and negative signaling molecules within the FcεRI signalosome. The results highlight the ability of ITAM-based signaling to respond to various ITAM phosphorylation patterns, Syk binding conformations, and the presence/absence of key regulatory molecules. These molecular mechanisms provide insight into how disparate immunoreceptors can utilize conserved signaling cascades to tailor their cellular outcomes. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
