| Autor: |
Sabzevari, H, Gillies, S D, Mueller, B M, Pancook, J D, Reisfeld, R A |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; September 1994, Vol. 91 Issue: 20 p9626-9630, 5p |
| Abstrakt: |
A genetically engineered fusion protein consisting of a human/mouse chimeric anti-ganglioside GD2 antibody (ch14.18) and recombinant human interleukin 2 (rhIL-2) was tested for its ability to target rhIL-2 to tumor sites and stimulate immune effector cells sufficiently to achieve effective tumor cell lysis in vivo. The ch14.18-IL-2 fusion protein proved more effective than equivalent doses of rhIL-2 in suppressing dissemination and growth of human neuroblastoma in an experimental hepatic metastases model of scid (severe combined immunodeficiency) mice reconstituted with human lymphokine-activated killer cells. The ch14.18-IL-2 fusion protein was also more proficient than equivalent doses of rhIL-2 in prolonging the life-span of these animals. This recombinant antibody-cytokine fusion protein may prove useful for future treatment of GD2-expressing human tumors in an adjuvant setting. |
| Databáze: |
Supplemental Index |
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