| Autor: |
Eriksson, P, Kallin, B, van 't Hooft, F M, Båvenholm, P, Hamsten, A |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; March 1995, Vol. 92 Issue: 6 p1851-1855, 5p |
| Abstrakt: |
Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymorphism in the PAI-1 promoter is associated with higher plasma PAI-1 activity. The prevalence of the 4G allele is significantly higher in patients with myocardial infarction before the age of 45 than in population-based controls (allele frequencies of 0.63 vs. 0.53). Both alleles bind a transcriptional activator, whereas the 5G allele also binds a repressor protein to an overlapping binding site. In the absence of bound repressor, the basal level of PAI-1 transcription is increased. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
