| Autor: |
Renauld, J C, Druez, C, Kermouni, A, Houssiau, F, Uyttenhove, C, Van Roost, E, Van Snick, J |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; June 1992, Vol. 89 Issue: 12 p5690-5694, 5p |
| Abstrakt: |
Interleukin 9 (IL-9) is a T-cell-derived lymphokine that induces the proliferation of various lymphoid and hemopoietic cells. A cDNA clone encoding the murine IL-9 receptor was isolated by expression cloning in COS cells and screening with 125I-labeled IL-9. Transient expression of this cDNA produced high-affinity binding sites for IL-9. The predicted 52-kDa protein contains a putative signal peptide and a typical transmembrane domain. A cDNA for the human homologue was isolated by cross-hybridization. Transfection of this cDNA in a murine T-cell clone conferred responsiveness to human IL-9. Sequence analysis revealed that the IL-9 receptor belongs to the recently described hematopoietin receptor super-family and is expressed in membrane-bound and soluble forms. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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