| Autor: |
Ip, N Y, Ibáñez, C F, Nye, S H, McClain, J, Jones, P F, Gies, D R, Belluscio, L, Le Beau, M M, Espinosa, R, Squinto, S P |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; April 1992, Vol. 89 Issue: 7 p3060-3064, 5p |
| Abstrakt: |
Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4. |
| Databáze: |
Supplemental Index |
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