| Autor: |
Plaxco, K W, Mathiowetz, A M, Goddard, W A |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; December 1989, Vol. 86 Issue: 24 p9841-9845, 5p |
| Abstrakt: |
Molecular dynamics simulations were coupled with experimental data from biochemistry and genetics to generate a theoretical structure for the binding domain of Hin recombinase complexed with the hix site of DNA. The theoretical model explains the observed sequence specificity of Hin recombinase and leads to a number of testable predictions concerning altered sequence selectivity for various mutants of protein and DNA. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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