| Autor: |
Fontan, E, Briend, E, Saklani-Jusforgues, H, d'Alayer, J, Vandekerckhove, J, Fauve, R M |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; August 1994, Vol. 91 Issue: 18 p8353-8357, 5p |
| Abstrakt: |
We purified to apparent homogeneity a human urinary glycoprotein of 92 kDa (HGP.92) that, administered intravenously at 250 micrograms/kg, fully protected mice against a lethal inoculum of Listeria monocytogenes. Since HGP.92 protected scid mice, which lack B and T lymphocytes, this increased resistance to Listeria did not appear to be lymphocyte mediated. Furthermore, inflammatory macrophages incubated with 6 nM HGP.92 inhibited the growth of Lewis carcinoma cells in vitro. These two activities appeared to depend on an oligosaccharide moiety, as they were lost after N-Glycanase treatment of HGP.92. Thus, the biological activity of HGP.92 was in some way related to a glycan moiety. |
| Databáze: |
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