Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA.

Autor: Dempcy, R O, Luo, J, Bruice, T C
Zdroj: Proceedings of the National Academy of Sciences of the United States of America; April 1996, Vol. 93 Issue: 9 p4326-4330, 5p
Abstrakt: Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)9U.r(Ag)9A.r(Up)9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic procedures are provided for tetrameric adenosyl RNG [r(Ag)3A].
Databáze: Supplemental Index