| Autor: |
Korman, A J, Maruyama, J, Raulet, D H |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; January 1989, Vol. 86 Issue: 1 p267-271, 5p |
| Abstrakt: |
We have located a T-cell receptor variable (V) delta gene segment immediately 3' of the delta constant (C) region gene and 5' to the known joining (J) alpha gene segments. This V delta gene is in the opposite transcriptional polarity to C delta and has rearranged to C delta by inversion in a gamma/delta-expressing hybridoma, DN7.3. This V delta gene is commonly rearranged in adult but not fetal gamma/delta-expressing thymocytes and has not been observed among alpha gene rearrangements reported to date. The reciprocal joining sequence isolated from this cell line contains N region nucleotides between the recombination signal sequences, in contrast to previously analyzed reciprocal joints. The results are discussed in the context of models accounting for ordered V gene usage during lymphocyte development. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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