| Autor: |
Mayo, K E, Cerelli, G M, Lebo, R V, Bruce, B D, Rosenfeld, M G, Evans, R M |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; January 1985, Vol. 82 Issue: 1 p63-67, 5p |
| Abstrakt: |
We have isolated and characterized overlapping clones from phage lambda and cosmid human genomic libraries that predict the entire structure of the gene encoding the precursor to human growth hormone-releasing factor. The gene includes five exons spanning 10 kilobase pairs of human genomic DNA. There appears to be a segregation of distinct functional regions of the GRF precursor and its mRNA into the five exons of the gene. The DNA sequences of all exons, intron/exon boundaries, and 5' and 3' flanking regions are presented. Dot-blot analysis of DNA from high resolution dual-laser-sorted human chromosomes indicates that the single-copy growth hormone-releasing factor gene is located on human chromosome 20. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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