| Autor: |
Barry, D I, Kikvadze, I, Brundin, P, Bolwig, T G, Björklund, A, Lindvall, O |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; December 1987, Vol. 84 Issue: 23 p8712-8715, 4p |
| Abstrakt: |
Norepinephrine-rich cell suspensions, prepared from the locus coeruleus region of rat fetuses, were grafted bilaterally into the hippocampus of rats made hypersensitive to hippocampal kindling by a neurotoxic lesion of the central catecholamine system. The animals with grafts showed a marked suppression of the onset and progression of kindling-induced epilepsy, and this effect was correlated with the degree of graft-derived noradrenergic innervation of the host hippocampal formation. We conclude that grafted neurons can modulate the excitability of epileptic brain regions. |
| Databáze: |
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