| Autor: |
Kaestner, K H, Christy, R J, McLenithan, J C, Braiterman, L T, Cornelius, P, Pekala, P H, Lane, M D |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; May 1989, Vol. 86 Issue: 9 p3150-3154, 5p |
| Abstrakt: |
The cDNAs for two putative glucose transporters from mouse 3T3-L1 adipocytes were isolated and sequenced. One of these cDNAs encodes the murine homolog of the human hepG2/erythrocyte glucose transporter, termed GT1. GT1 mRNA is most abundant in mouse brain and is expressed in both 3T3-L1 preadipocytes and adipocytes. The other cDNA encodes a glucose transporter-like protein, termed GT2, that has a unique amino acid sequence and tissue distribution. GT2 cDNA encodes a protein with 63% amino acid sequence identity and a similar structural organization to GT1. GT2 mRNA is found at high levels in mouse skeletal muscle, heart, and adipose tissue, all of which exhibit insulin-stimulated glucose uptake. GT2 mRNA is absent from 3T3-L1 preadipocytes but is induced dramatically during differentiation into adipocytes. This increase in mRNA content correlates closely with the acquisition of insulin-stimulated glucose uptake. We propose that GT2 is an insulin-regulated glucose transporter. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
