| Autor: |
Sklar, Marshall D., White, Beverly J., Rowe, Wallace P. |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; October 1974, Vol. 71 Issue: 10 p4077-4081, 5p |
| Abstrakt: |
While C-type RNA viruses are known to induce leukemias and lymphomas, oncogenic transformation of lymphoid cells by them in vitrohas not been reported. In this study, splenocytes from female BALB/c mice were infected in vitrowith Abelson virus, a C-type RNA virus that induces nonthymic lymphomas and plasmacytomas in mice. The cells were transplanted into recipients of different karyotype, either male BALB/c mice or hybrid BALB/c × AL/N (CALF1) mice, which bear the Rb(5.19)1Whtranslocation. Transplants of eight of the resulting tumors (one plasmacytoma and seven lymphomas) contained cells of donor BALB/c karyotype, indicating that transformation of splenocytes occurred in vitro. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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