| Autor: |
Fullerton, W. Wardle, Potter, Reginald, Low, Barbara W. |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; August 1970, Vol. 66 Issue: 4 p1213-1219, 7p |
| Abstrakt: |
Bovine proinsulin has been crystallized under a variety of conditions at both neutral and acid pH. Microtechniques were employed with sample weights of about 200 μg and volumes of 5-20 μl. The crystalline preparations all differ from each other morphologically.X-ray photographs of one form, tetragonal bipyramids grown at pH 3 with added ammonium sulphate solution, established the space group P41212 (or its enantiomorph P43212). The cell dimensions are a= 50.8 ± 0.2 Å, c= 148.0 ± 0.4 Å. The asymmetric unit in this form is a dimer of proinsulin which is also the dominant species in solution at this pH. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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