| Autor: |
Gauchat, J F, Khandjian, E W, Weil, R |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; September 1986, Vol. 83 Issue: 17 p6430-6434, 5p |
| Abstrakt: |
Blast formation and mitotic activation of G0-arrested mouse thymocytes were triggered by the addition of concanavalin A plus interleukin 2 (IL-2) to the culture medium. When added alone, Con A induces within 6 hr a complex reprogramming ("priming") that comprises the activation of the IL-2 receptor gene. The primed thymocytes are competent to interact with IL-2 and to respond to its growth-promoting effect, which corresponds to blast formation and mitotic activation. Cyclosporin A, an immunosuppressive cyclic peptide of fungal origin, prevents in T lymphocytes the activation of a set(s) of genes encoding lymphokines and the IL-2 receptor but does not affect their expression once they have been activated. The biomedical implications of these observations are discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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