| Autor: |
Nishimoto, N, Kubagawa, H, Ohno, T, Gartland, G L, Stankovic, A K, Cooper, M D |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; July 1991, Vol. 88 Issue: 14 p6284-6288, 5p |
| Abstrakt: |
Precursors of B cells, which constitute a subpopulation of the lymphocytes in bone marrow, can be identified by their surface expression of nonimmunoglobulin markers and the absence of immunoglobulin kappa and lambda light chains. Most pre-B cells synthesize mu heavy chains but, without light-chain partners, these undergo rapid cytoplasmic degradation. In the present study, we demonstrate that late stage pre-B cells, like their neoplastic counterparts, express low levels of a surface receptor composed of mu chains paired with a surrogate light-chain complex formed by Vpre-B and lambda 5-like proteins. The data define a previously suspected but unrecognized stage in normal pre-B-cell differentiation. Expression of a clonally diverse receptor renders this population of immature B-lineage cells potentially vulnerable to clonal selection by antigens and idiotypic interactions. |
| Databáze: |
Supplemental Index |
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