| Autor: |
Langdon, W Y, Hartley, J W, Klinken, S P, Ruscetti, S K, Morse, H C |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; February 1989, Vol. 86 Issue: 4 p1168-1172, 5p |
| Abstrakt: |
Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B and pro-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence shows no homology with known oncogenes but some similarity to the yeast transcriptional activator GCN4. A 100-kDa gag-cbl fusion protein, with no detectable kinase activity, is responsible for the cellular transformation. The cellular homologue of v-cbl, present in mouse and human DNA, is expressed in a range of hemopoietic lineages. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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