| Autor: |
Albertini, R J, Castle, K L, Borcherding, W R |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; November 1982, Vol. 79 Issue: 21 p6617-6621, 5p |
| Abstrakt: |
Rare thioguanine-resistant T lymphocytes, present in vivo in human peripheral blood, were isolated and grown in vitro as thioguanine-resistant cultured T cells. The conditions for their selection in vitro were such that thioguanine resistance had to have arisen in vivo. The mutant cells bore T-cell surface markers, maintained their thioguanine resistance in vitro in the presence or absence of selection, and were deficient in hypoxanthine-guanine phosphoribosyltransferase activity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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