| Autor: |
Newcombe, D S, Ciosek, C P, Ishikawa, Y, Fahey, J V |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; August 1975, Vol. 72 Issue: 8 p3124-3128, 5p |
| Abstrakt: |
The human synoviocyte increases its intracellular adenosine 3':5'-cyclic monophosphate (cAMP) concentration significantly after incubation with prostaglandin E1, prostaglandin E2, or l-epinephrine. The cells can be desensitized to these same hormones. Hormone-induced desensitization is receptor site specific and associated with a significant increase in intracellular 3':5'-cyclic AMP phosphodiesterase (EC 3.1.4. 17; 3':5'-cyclic AMP 5'-nucleotidohydrolase) activity, whereas cAMP-induced desensitization is not hormone specific. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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