| Autor: |
Paaren, H E, Hamer, D E, Schnoes, H K, DeLuca, H F |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; May 1978, Vol. 75 Issue: 5 p2080-2081, 2p |
| Abstrakt: |
An efficient procedure for the direct C-1 hydroxylation of vitamin D compounds has been developed. The method involves conversion of vitamin D3 tosylates to 3,5-cyclovitamin D derivatives, allylic oxidation with selenium dioxide, and acid-catalyzed solvolysis to the 1 alpha-hydroxyvitamin D analogs. When applied to vitamin D3,25-hydroxyvitamin D3, and vitamin D2, this sequence give the corresponding 1alpha-hydroxylated derivatives in 10-15% yield. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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