An Epstein--Barr virus early protein induces cell fusion.
| Autor: | Bayliss, G J, Wolf, H |
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| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America; November 1981, Vol. 78 Issue: 11 p7162-7165, 4p |
| Abstrakt: | Superinfection of Raji cells with Epstein--Barr virus (EBV) leads to syncytium formation. Studies using metabolic inhibitors and amino acid analogues suggest that the fusion-inducing factor belongs to the early group of virus-specified proteins. Induction of early EBV protein synthesis in Raji cells by using various chemicals also leads to syncytium formation, indicating that the fusion process is not caused by a virion membrane protein introduced into the cells upon infection. The relevance of these findings to the association of EBV with carcinoma of the nasopharynx is discussed. |
| Databáze: | Supplemental Index |
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