| Autor: |
Chattopadhyay, S K, Morse, H C, Makino, M, Ruscetti, S K, Hartley, J W |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; May 1989, Vol. 86 Issue: 10 p3862-3866, 5p |
| Abstrakt: |
C57BL/6 mice infected with a mixture of murine leukemia viruses (MuLV) develop a syndrome characterized by lymphoproliferation and profound immunodeficiency. Analyses of this viral mixture (LP-BM5 MuLV) showed that it includes replication-competent ecotropic and mink cell focus-inducing MuLV and defective viruses with genome sizes of 3.8-6.5 kilobases. The ecotropic and mink cell focus-inducing MuLV biologically cloned from the mixture did not induce disease, whereas viral preparations containing the ecotropic MuLV and 4.8-kilobase defective virus were active. Cells producing the 4.8-kilobase defective virus expressed an unusual gag-encoded polyprotein of Mr 60,000. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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