| Autor: |
D'Angelo, G, Struman, I, Martial, J, Weiner, R I |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; July 1995, Vol. 92 Issue: 14 p6374-6378, 5p |
| Abstrakt: |
A number of factors both stimulating and inhibiting angiogenesis have been described. In the current work, we demonstrate that the angiogenic factor vascular endothelial growth factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously shown for basic fibroblast growth factor. The antiagiogenic factor 16-kDa N-terminal fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that activation and inhibition of MAPK may play a central role in the control of angiogenesis. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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