| Autor: |
Abdel-Radi, Mahmoud, Shehata, Mohamed, Mostafa, Magdi Mohammad, Aly, Mohamed Omar M. |
| Zdroj: |
Eye; June 2023, Vol. 37 Issue: 8 p1545-1552, 8p |
| Abstrakt: |
Objectives: To assess and compare the six-month outcome of the two-step transepithelial phototherapeutic keratectomy- photorefractive keratectomy (PTK-PRK) and the single-step transepithelial PRK for myopia and myopic astigmatism. Methods: A prospective randomized study. The study enrolled 100 eyes of 50 patients with mild to moderate myopia or myopic astigmatism stratified into two groups, PTK-PRK (n= 50 eyes) and single step PRK (n= 50 eyes). Primary outcome measures were visual acuity and manifest refraction. Secondary outcome measures were epithelial healing duration, post-PRK pain scores and 3-month postoperative haze grading. Results: Preoperative characteristics were similar in both groups (pvalue > 0.05). The mean uncorrected distance visual acuity (UDVA) at 1 week, 1 month, 3 and 6 months was significantly better in the single-step PRK group than in the two-step PTK-PRK group (p< 0.001). The mean manifest sphere, cylinder and spherical equivalent showed a significant difference at all follow up visits in favour of the single-step PRK (pvalue < 0.001). Epithelial healing duration was faster in single-step PRK (pvalue < 0.001). Pain scores were significantly lower following single-step PRK at 8 h, 1 day, 3 days (pvalue < 0.001) but were similar at the 7th day. Haze scores showed no statistical difference between the two groups at 3-month follow-up. Conclusion: The two transepithelial PRK techniques were effective in correcting mild to moderate myopia and myopic astigmatism. However, Single-step transepithelial PRK achieved faster visual recovery, better refractive outcome and shorter epithelial healing time with less post-PRK pain. Clinical trials registry: (Clinical Trials.gov Identifier): NCT04710082. |
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