| Autor: |
Ben Hur, Daniel, Kapach, Gal, Wani, Naiem Ahmad, Kiper, Edo, Ashkenazi, Moshe, Smollan, Gill, Keller, Natan, Efrati, Ori, Shai, Yechiel |
| Zdroj: |
Journal of Medicinal Chemistry; 20220101, Issue: Preprints |
| Abstrakt: |
Lung infection is the leading cause of morbidity and mortality in cystic fibrosis (CF) patients and is mainly dominated by Pseudomonas aeruginosa. Treatment of CF-associated lung infections is problematic because the drugs are vulnerable to multidrug-resistant pathogens, many of which are major biofilm producers like P. aeruginosa. Antimicrobial peptides (AMPs) are essential components in all life forms and exhibit antimicrobial activity. Here we investigated a series of AMPs (d,l-K6L9), each composed of six lysines and nine leucines but differing in their sequence composed of l- and d-amino acids. The d,l-K6L9peptides showed antimicrobial and antibiofilm activities against P. aeruginosafrom CF patients. Furthermore, the data revealed that the d,l-K6L9peptides are stable and resistant to degradation by CF sputum proteases and maintain their activity in a CF sputum environment. Additionally, the d,l-K6L9peptides do not induce bacterial resistance. Overall, these findings should assist in the future development of alternative treatments against resistant bacterial biofilms. |
| Databáze: |
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