| Abstrakt: |
New PVC membrane electrodes for the determination of sulfadiazine (SDZ) are presented. The electrodes are fabricated with conventional and tubular configurations with a graphite-based electrical contact, and no internal reference solution. The selective membranes consist of bis(triphenylphosphoranilidene)ammonium·SDZ (electrode A), tetraoctylammonium bromide (electrode B), or iron(II)-phthalocyanine (FePC) (electrode C) electroactive materials dispersed in a PVC matrix of o-nitrophenyl octyl ether (o-NPOE) plasticizer. The sensors A, B, and C displayed linear responses over the concentration ranges 1.0 × 10−2– 1.0 × 10−5, 1.0 × 10−2– 7.5 × 10−6, and 3.2 × 10−2– 7.0 × 10−6mol l−1(detection limits of 1.09, 2.04 and 0.87 jug ml−1) with anionic slopes of −57.3 ± 0.1, −46.7 ± 0.5, and −65.1 ± 0.2 mV decade−1, respectively. No effect from pH was observed within 4.0 – 5.5, 4.8 – 10, and 4.5 – 8, respectively, and good selectivity was found. The sensors were applied to the analysis of pharmaceuticals and biological fluids in steady state and in flow conditions. |
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