Accumulation of cyanide and thiocyanate in haemodialysis patients.

Autor: Hasuike, Yukiko, Nakanishi, Takeshi, Moriguchi, Rintarou, Otaki, Yoshinaga, Nanami, Masayoshi, Hama, Yasue, Naka, Miki, Miyagawa, Koji, Izumi, Masaaki, Takamitsu, Yoshihiro
Zdroj: Nephrology Dialysis Transplantation; June 2004, Vol. 19 Issue: 6 p1474-1479, 6p
Abstrakt: Cyanide is a toxic agent, and its detoxification product, thiocyanate, may be a major pathogenetic substance in uraemia. Recent studies examining the myeloperoxidase(MPO)/thiocyanate system have suggested a link between thiocyanate and atherosclerosis. However, inaccuracies in conventional assays for cyanide and thiocyanate have limited the understanding of their metabolism in haemodialysis (HD) patients.
Databáze: Supplemental Index