5-Oxo-5H-benzo[e]isochromeno-[4,3-b]indole, a New Type of Highly Sarcomagenic Lactone

Autor: Lacassagne, A., Buu-Hoi, N. P., Zajdela, F., Jacquigmon, P., Mangane, M.
Zdroj: Science; October 1967, Vol. 158 Issue: 3799 p387-388, 2p
Abstrakt: The title compound, which belongs to a new synthetic group of polycyclic lactones derived from isocoumarin, exhibits a remarkably high degree of carcinogenicity in situwhen injected in mice. Cancer-inducing activity has also been found in similar isocoumarins, a family known to include many naturally occurring substances.
Databáze: Supplemental Index