Use of Methotrexate in Older Patients
| Autor: | Tett, Susan E., Triggs, Edward J. |
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| Zdroj: | Drugs & Aging; December 1996, Vol. 9 Issue: 6 p458-471, 14p |
| Abstrakt: | Methotrexate is eliminated almost entirely by the kidneys. The risk of methotrexate toxicity is therefore increased in patients with poor renal function, most likely as a result of drug accumulation. Declining renal function with age may thus be an important predictor of toxicity to methotrexate. |
| Databáze: | Supplemental Index |
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