| Autor: |
Pue, M. A., Ransley, J. A., Writer, D. J., Dean, A. J., Franklin, E. R., Beattie, I. G., Ross, D. A. |
| Zdroj: |
European Journal of Drug Metabolism and Pharmacokinetics; July 1989, Vol. 14 Issue: 3 p209-219, 11p |
| Abstrakt: |
SK&F L-94901 is a novel thyromimetic, structurally related to thyroxine. The absorption, distribution, excretion and metabolism of radiochemically labelled [14C]-SK&F L-94901 has been investigated in the rat, dog and cynomolgus monkey. Oral absorption from solution was l ow or moderate in all three species. The compound was widely distributed and rapidly excreted, although traces of radioactivity were still evident in some tissues at 7 days post-dose, particularly in the kidney where radioactivity was located in an area approximating to the corticomedullary junction. Elimination of [14C]-SK&F L-94901 was both metabolic, mediated by the liver, and renal. The major metabolic routes of elimination were via oxidative deamination to lactate and acetate derivatives. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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