Synthesis of Nonselective Sorbents Modified with Carbon Nanomaterials and Their Hemocompatibility

Autor: Lykov, A. P., Opoku, M., Rachkovskaya, L. N., Surovtseva, M. A., Bondarenko, N. A., Kim, I. I., Rachkovsky, E. E., Volodin, A. M., Poveshchenko, O. V.
Zdroj: Nanobiotechnology Reports; April 2022, Vol. 17 Issue: 2 p219-226, 8p
Abstrakt: Abstract—: A search for promising nonselective sorbents based on composite materials, including using carbon nanomaterials, is an urgent task of resuscitation and toxicology. The synthesis and estimation of the biocompatibility of sorbents based on gamma-aluminum oxide and polydimethylsiloxane, modified with single-walled carbon nanotubes or carbon nanofibers, are carried out. It is detected that the synthesized sorbents adsorb low and medium molecular weight substances on their surface. Moreover, it is found that there is a toxic effect on red blood cells (hemolysis) occurs with prolonged exposure (120 h), short-term (5 min) exposure of the components of human peripheral blood with the sorbents leads to a loss in the number of platelets and leukocytes, mainly granulocytes, of mononuclear cells of the peripheral blood, as well as short-term and long-term contact of the blood components with the samples of sorbents contributes to a decrease in the metabolic activity of the cells and the activation of nitric-oxide production. Based on the results obtained, it can be assumed that the sorbent based on γ aluminum oxide and polydimethylsiloxane, modified with carbon nanomaterials, is promising for the development of nonselective sorbents.
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