| Autor: |
Ebohon, Osamudiamen, Irabor, Francis, Ayevbuomwan, Merit Esewi, Omoregie, Ehimwenma Sheena |
| Zdroj: |
Advances in Traditional Medicine; June 2022, Vol. 22 Issue: 2 p347-358, 12p |
| Abstrakt: |
Oxidative stress, already implicated in malaria infection has been identified as one of the major contributors to the pathophysiology of malaria. This study was aimed at evaluating the effects of methanol extracts of Tetrorchidium didymostemonleaf and stem bark on Plasmodium bergheiinduced oxidative stress in the liver, spleen and brain of mice. P. berghei-infected mice were sacrificed on day 5 of the experiment after four days of consecutive administration of T. didymostemonextracts (250 and 500 mg/kg body weight). Thereafter, biochemical analysis and histopathological examination were carried out. The leaf extract had a significantly higher (P< 0.05) ability to reduce parasite induced alterations of antioxidant enzyme activities compared with the stem bark extract. Malondialdehyde level was significantly higher (P< 0.05) while glutathione peroxidase and catalase activities were lower in the negative control (infected mice, without treatment) relative to the treated groups. The leaf extract at 500 mg/kg body weight had a higher ability to ameliorate changes in oxidative stress and reduce hepatic injury induced by P. bergheiin comparison with the other doses. The leaf extract (500 mg/kg) was able to reduce significantly hepatomegaly induced by P. berghei.Similarly, histopathological observation of the organs (liver and spleen) shows relative reversal of the cellular and morphological alteration induced by P. bergheiinfection following leaf extract administration. Our study suggests that treatment of P. bergheiinfected mice with T. didymostemonleaf extract during early infection reduces oxidative stress by preventing lipid peroxidation and normalizing glutathione peroxidase and catalase activities. |
| Databáze: |
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